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| Tubular vacuolar change | ||
| Etiology •Hypokalemia. •Uncontrolled diabetes mellitus. •Mannitol administration. •Intravenous pyelography (contrast induced). | ||
| Pathogenesis •Various substances in the tubular lumina can be reabsorbed into tubular cells by pinocytotic vesicles which can then fuse with endogenous lysozomes to produce large membrane bound vacuoles. •Vacuolar change of tubular cells is a reversible condition., | ||
| Epidemiology •The epidemiology is diverse. •Vacuolar change is a non-specific cellular change. | ||
| General Gross Description •There are no specific gross abnormalities. •The finding is microscopic. •Examples: | ||
| General Microscopic Description •The epithelial cells of the proximal tubules show marked cytoplasmic vacuolization. •Examples: | ||
| Clinical Correlation •Patients may manifest signs, symptoms and clinical laboratory values of acute renal failure. | ||
| References •Renal Disease Classification and Atlas of Tubulo-Interstitial Diseases.Churg et.al. (eds.). New York: Igaku-Shoin, 1985 pp. 161, 168-171. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Tubular vacuolar change
| Synopsis by: Harold Yamase M.D. (T71000M50070)[188]
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