| Acquired Cystic Disease
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Etiology
•Unknown.
|
Pathogenesis
•Unknown.
•One hypothesis is
that abnormal tubular cell proliferation might be the means by which cysts
develops in these end stage kidneys.
•Another theory is that cysts develop from tubular
obstruction by calcium oxalate crystals.,
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Epidemiology
•By
definition, this condition occurs in end stage renal disease.
•This
condition is apparently independent of the disease type that led to end
stage kidney disease.
|
General Gross Description
•Acquired cystic disease is defined as
the development of cortical and medullary cysts in patients with end stage
kidney disease from noncystic causes.
•Both kidneys show multiple cysts
of varying sizes in a background of sclerosing parenchymal
changes.
•Although many cysts are present, they are not as plentiful as
in adult polycystic kidney disease.
•Examples:
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General Microscopic Description
•The cysts are lined by tubular epithelial cells that may be flat to
cuboidal to hyperplastic.
•Examples:
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, p. 937.
•Primer on
Kidney Diseases 1994 (National Kidney Foundation), Arthur Greenberg editor.
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| Acquired Cystic Disease
| | Synopsis by: Harold Yamasel M.D. (T71000M33400)[245]
| |