| Transitional cell carcinoma
|
Etiology
•Similar to transitional cell carcinoma of the bladder.
•Patients with
analgesic abuse nephropathy have increased risk for developing transtional
cell carcinoma of the renal pelvis.
|
Pathogenesis
•Same as for transitional cell
carcinoma of the bladder.,
|
Epidemiology
•Similar
to transtional cell carcinoma of the bladder.
|
General Gross Description
•The carcinoma predominantly involves the mucosal surfaces of the renal
pelvis and calyces and may secondarily invade the renal parenchyma.
•The
tumor is papillary to nodular on viewing from the mucosal aspect.
•Tumors
involving the uretero-pelvic junction may obstruct urine outflow and cause
hydronephrosis.
•Examples:
|
General Microscopic Description
•The tumor histologically tends to show a papillary
architecture.
•The papillae show a central fibrovascular core and are
lined by transitional epithelial cells.
•The neoplastic transitional
epithelial cells show varying degrees of nuclear changes which is the basis for tumor grading.
•Examples:
|
References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 987-988.
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| Transitional cell carcinoma
| | Synopsis by: Harold Yamase M.D. (T72000M81303)[197]
| |