| Granulomatous Cystitis (BCG)
|
Etiology
•Intravesical BCG therapy for transitional cell carcinoma.
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Pathogenesis
•BCG is an attenuated live acid fast bacilli which like other mycobacteria
will incite a granulomatous tissue reaction.
•The organisms do not reproduce but the antigens elicit an immune response which eradicates the neoplastic cells.,
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Epidemiology
•Since BCG is used in bladder carcinomas as therapy, the epidemiology of cases will be that of bladder
carcinomas.
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General Gross Description
•BCG is used in the treatment of some bladder carcinomas.
•The gross
appearance of cases will be dominated by the carcinoma that is present
rather than by the effect of BCG therapy.
•Examples:
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General Microscopic Description
•The mucosa of the urinary
bladder shows granulomatous inflammation.
•Examples:
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Clinical Correlation
•The clinical
features will be dependent on the carcinoma present.
•Rarely organisms reproduce and actually cause mycobacterial disease.
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References
•Urological Pathology. Murphy WM (ed). Philadelphia: Saunders, 1989, p. 100.
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| Granulomatous Cystitis (BCG)
| | Synopsis by: Harold Yamase M.D. (T74000M44001)[179]
| |