| Squamous metaplasia prostate
|
Etiology
•Squamous metaplasia is usually an adaptive response of
marginally viable epithelial cells adjacent to infarcts, which in turn may
be secondary to massive prostatic enlargement.
|
Pathogenesis
•The marginally viable
prostatic epithelial cells adjacent to an infarct will undergo squamous
metaplasia to survive the circumstances of the local environment.,
|
Epidemiology
•The epidemiology is that of benign prostatic
hyperplasia.
|
General Gross Description
•There
are no specific gross features.
•Since this metaplastic change is a
microscopic finding associated with benign prostatic hyperplasia (BPH), the
gross feature will be that of BPH.
•Examples:
|
General Microscopic Description
•The normal ductal and glandular
epithelial cells of the prostate are transformed to squamous cells.
•The
cells are no longer cuboidal or columnar but flattened.
•These cells may
show keratinization and squamous pearl formation.
•Squamous metaplasia in
the prostate can be seen adjacent to infarcts.
•Examples:
|
Clinical Correlation
•Squamous metaplasia of the
prostate can be seen adjacent to infarcts due to prostatic
enlargement.
•The clinical picture will be that of benign prostatic
hyperplasia.
|
References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 48.
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| Squamous metaplasia prostate
| | Synopsis by: Harold Yamase M.D. (T77100M73220)[178]
| |