| Hypospadias
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Etiology
•Developmental abnormality.
•There is some evidence for genetic
influences; sibling of a child with hypospadias has an increased (14%)
chance of having hypospadias.
|
Pathogenesis
•Developmental malformation of the urethral groove and formation of the
urethral canal.,
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Epidemiology
•Hypospadias is one of the more common congenital malformations, occuring in
the United States at a frequency of 28.23 per 10,000 total births.
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General Gross Description
•Hypospadias is the abnormal location of the urethral meatus ventral to
the normal glanular tip.
•The urethral meatus may open on the ventral
surface of the penis, at the base of the penis or the perineum.
•Examples:
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General Microscopic Description
•No
specific microscopic features. Hypospadias is a gross anatomic abnormality.
•Examples:
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Clinical Correlation
•Usually does not need surgical correction.
|
References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 440 and 1007.
•Neonatology, 4th edition, Avery et al. (eds), New York: Lippincott, 1994. pp. 905-906.
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| Hypospadias
| | Synopsis by: Harold Yamase M.D. (T76000M23030)[242]
| |