| Endodermal Sinus Tumor
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Etiology
•Unknown.
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Pathogenesis
•Unknown.
•Endodermal sinus tumor is a type of malignant germ cell tumor.,
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Epidemiology
•Most testicular endodermal sinus tumors of the pure type occur in infants and children under the age of 3.
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General Gross Description
•Tumors are usually well demarcated from surrounding tissues.
•On cut section the tumors are tan to yellow, usually solid with a mucinous quality.
•Microcysts and areas of hemorrhage may be present.
•Examples:
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General Microscopic Description
•Histologically the tumor tends to show a network arrangement of tumor cells with glandular and papillary structures.
•Some of the papillary structures resemble glomeruli (Schiller-Duval bodies).
•Scattered isolated or clustered groups of globular hyaline droplets are present which contain alpha fetoprotein and alpha 1 antitrypsin.
•Examples:
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1018.
• Urological Pathology, Murphy WM (ed), Philadelphia: WB Saunders, 1989, pp. 336-340.
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| Endodermal Sinus Tumor
| | Synopsis by: Harold Yamase M.D. (T78000M90713)[467]
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