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| Dysgerminoma | ||
| Etiology • Unknown | ||
| Pathogenesis • Unknown., | ||
| Epidemiology • Usually teenage girls or young women • 2% ovarian neoplasms • 1/2 of malignant germ cell neoplasms • Gonadal dysgenesis may be setting for some | ||
| General Gross Description • Usually unilateral and confined to ovary. • Homogenous tan, fleshy lesion • Usually without hemorrhage or necrosis •Examples: | ||
| General Microscopic Description • Identical to seminoma • Cells in nests separated by delicate fibrovascular septae • Septae may contain lymphocytes or even granuloma • Cells have round to oval nuclei, relatively clear cytoplasm, and well defined cell borders. •Examples: | ||
| Clinical Correlation • If confined to the ovary and <10 cms. cure can be achieved with surgery alone • Exquisitely radiosensitive if metastatic. | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1071-1073. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Dysgerminoma
| Synopsis by: Melinda Sanders M.D. (T87000M90603)[271]
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