| Fusion Defects of Mullerian Ducts
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Etiology
• Unknown
• ? abnormal hormonal stimulation in utero
• ? genetic
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Pathogenesis
• Failure of fusion of the Mullerian ducts results in bicornuate uterus
• Failure of degeneration of the septum may result in septae of varying lengths including septation extending into the upper vagina resulting in a uterus didelphys with double upper vagina, cervix and endometrial cavity,
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Epidemiology
• Rare
• May be associated with urinary tract abnormalities
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General Gross Description
• External view of didelphys shows bifurcate uterus
•Examples:
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General Microscopic Description
• Microscopic appearance unremarkable
•Examples:
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Clinical Correlation
• Associated with spontaneous abortions or infertility
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References
• Blaustein's Pathology of the Female Genital Tract, 4th ed. Kurman RJ (ed). New York: Springer-Verlag, 1994, pp. 368.
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| Fusion Defects of Mullerian Ducts
| | Synopsis by: Melinda Sanders M.D. (T82000M20000)[311]
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