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| Intraepithelial Neoplasia (Dysplasia)(Squamous Intraepithelial Lesion) | ||
| Etiology •human papillomavirus infection (HPV) •types 6 and 11 associated with low grade lesions •types 16, 18, 31, 33, 35 etc associated with high grade lesions •cigarette smoking may also play a role | ||
| Pathogenesis •low grade lesions probably represent self limited viral infections with the cellular features representing viral cytopathic effects •high grade lesions probably represent transformation of the host genome by viral integration, | ||
| Epidemiology •young women with multiple sexual partners or •young women with a high risk partner | ||
| General Gross Description •white patches on the cervix •when viewed with colposcopy (an illuminated magnifying instrument) may see abnormal vascularization, irregular surface •Examples: | ||
| General Microscopic Description •loss of a single basal layer with crowding of the squamous cells, hyperchromasia of the nuclei, and failure to mature •mitotic figures seen above the basal cell layer •thickened epithelium which may contain koilocytes •mild (CIN1) when abnormal cells involve <1/3 of epithelial thickness; moderate (CIN2) when between 1/3 and 2/3 and severe (CIN3) when >2/3 of thickness •Examples: | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1048-1052 This link will directly take you to the relevant new literature Intraepithelial Neoplasia (Dysplasia)(Squamous Intraepithelial Lesion)
| Synopsis by: Melinda Sanders M.D. (T83000M74007)[264]
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