|
|
|
|
|
|
|
| Endometrial Stromal Sarcoma | ||
| Etiology •unknown | ||
| Pathogenesis •unknown, | ||
| Epidemiology •accounts for approximately 1-2% of endometrial malignancies •post-menopausal patients •not associated with estrogen excess | ||
| General Gross Description •intraluminal, friable, hemorrhagic gray white mass •may be fleshy •Examples: | ||
| General Microscopic Description •proliferation of stromal cells without glands •poorly circumscribed with infiltrative borders •nuclei are hyperchromatic and pleomorphic with scant cytoplasm •mitoses are abundant in the high grade neoplasms •Examples: | ||
| Clinical Correlation •patients present with post-menopausal vaginal bleeding •neoplasm invades locally but does not spread to regional lymph nodes •metasasizes via the blood stream to lungs •treatment by surgery | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1063 Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Endometrial Stromal Sarcoma
| Synopsis by: Melinda Sanders M.D. (T84000M89303)[21]
| |
|
|
|
|
|
|