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| Maligant Mixed Mullerian Tumor | ||
| Etiology •unknown •unassociated with unopposed estrogen | ||
| Pathogenesis •unknown, | ||
| Epidemiology •post-menopausal women •1-2% of uterine corpus malignancies | ||
| General Gross Description •fungating intraluminal neoplasms with poorly circumscribed borders which are often very bulky •hemorrhagic and necrotic •may protrude through the cervical os •Examples: | ||
| General Microscopic Description •composed of malignant epithelial and stromal components •adenocarcinoma and/or squamous carcinoma •stromal sarcoma or leiomyosarcoma (homologous) or •osteosarcoma, chrondrosarcoma or fibrosarcoma (heterologous) •Examples: | ||
| Clinical Correlation •symptoms of post-menopausal bleeding •spreads contiguously and usually to regional lymph nodes (like carcinoma) as well as hematogenously to lungs (like sarcoma) •treated with surgery +/- radiation therapy •prognosis related to extent of disease •overall 5 yr survival of 25-30% | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1062 Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Maligant Mixed Mullerian Tumor
| Synopsis by: Melinda Sanders M.D. (T84000M89513)[22]
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