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| Adenocarcinoma in situ of Cervix | ||
| Etiology • Associated with human papilloma virus infection, especially type 18. | ||
| Pathogenesis • Viral integration into host cell genome in fully malignant cells., | ||
| Epidemiology • Multiple sexual partners. • Partner with multiple partners. • Same as sexually transmitted disease. | ||
| General Gross Description • Not grossly recognizable. •Examples: | ||
| General Microscopic Description • Columnar cells with enlarged, hyperchromatic nuclei • Atypical nuclear chromatin • Piling up of cells in epithelium with loss of polarity to surface • Prominent nucleoli •Examples: | ||
| Clinical Correlation • May be detected on routine pap smear but difficult to assess • Usually found in conjunction with invasive disease | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1052. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Adenocarcinoma in situ of Cervix
| Synopsis by: Melinda Sanders M.D. (T83300M81402)[275]
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