| Adenocarcinoma in situ of Cervix
|
Etiology
• Associated with human papilloma virus infection, especially type 18.
|
Pathogenesis
• Viral integration into host cell genome in fully malignant cells.,
|
Epidemiology
• Multiple sexual partners.
• Partner with multiple partners.
• Same as sexually transmitted disease.
|
General Gross Description
• Not grossly recognizable.
•Examples:
|
General Microscopic Description
• Columnar cells with enlarged, hyperchromatic nuclei
• Atypical nuclear chromatin
• Piling up of cells in epithelium with loss of polarity to surface
• Prominent nucleoli
•Examples:
|
References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1052.
For Most Current Information Search Medline at National Library of Medicine
This link will directly take you to the relevant new literature
| Adenocarcinoma in situ of Cervix
| | Synopsis by: Melinda Sanders M.D. (T83300M81402)[275]
| |