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| Adenocarcinoma in situ of Cervix | ||
| Etiology Associated with human papilloma virus infection, especially type 18. | ||
| Pathogenesis Viral integration into host cell genome in fully malignant cells., | ||
| Epidemiology Multiple sexual partners. Partner with multiple partners. Same as sexually transmitted disease. | ||
| General Gross Description Not grossly recognizable. Examples: | ||
| General Microscopic Description Columnar cells with enlarged, hyperchromatic nuclei Atypical nuclear chromatin Piling up of cells in epithelium with loss of polarity to surface Prominent nucleoli Examples: | ||
| Clinical Correlation May be detected on routine pap smear but difficult to assess Usually found in conjunction with invasive disease | ||
| References Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1052. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Adenocarcinoma in situ of Cervix
| Synopsis by: Melinda Sanders M.D. (T83300M81402)[275]
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