| Extramammary Paget's Disease
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Etiology
• Unknown
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Pathogenesis
• Unknown,
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Epidemiology
• Rare
• Predominantly post-menopausal women
• May be associated with underlying adenocarcinoma (<15%)
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General Gross Description
• Red, crusting, itchy lesion
•Examples:
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General Microscopic Description
• Malignant cells individually infiltrate the squamous mucosa or in small nests
• Nuclei have large nucleolus and are hyperchromatic
• Cytoplasm contains mucin
•Examples:
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Clinical Correlation
• Treatment is usually surgical with an effort to clear the margins
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1042.
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| Extramammary Paget's Disease
| | Synopsis by: Melinda Sanders M.D. (T80100M85423)[267]
| |