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| Malignant Melanoma of Vulva | ||
| Etiology • Unknown in this non-sun exposed area. | ||
| Pathogenesis • Unknown, | ||
| Epidemiology • Less than 5% vulvar cancers • Less than 2% melanomas • Post-menopausal women | ||
| General Gross Description • May be reddish plaque or pigmented plaque or nodule •Examples: | ||
| General Microscopic Description • Composed of cells which infiltrate the mucosa, may nest at the mucosa-submucosal junction, and infiltrate underlying submucosa. • Large nuclei, very large nucleoli • May be epithelioid or spindle • May have numerous mitotic figures • Are not cohesive •Examples: | ||
| Clinical Correlation • Prognosis dependent on the depth of invasion • Widely disseminates and is non responsive to most modalities of therapy • Localized lesions treated surgically. | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1043. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Malignant Melanoma of Vulva
| Synopsis by: Melinda Sanders M.D. (T80100M87203)[268]
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