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| Normal Villi | ||
| Etiology • Not applicable | ||
| Pathogenesis • Not applicable, | ||
| Epidemiology • Not applicable | ||
| General Gross Description • Spongy red tissue comprising the bulk of the placenta bounded by fetal surface (chorionic plate) and maternal surface (basal plate) •Examples: | ||
| General Microscopic Description • Early in gestation villi are covered by a complete layer of syncytiotrophoblast overlying a complete layer of cytotrophoblast. • Trophoblast is keratin positive but serves as endothelium for intervillous space. • At term there is a single trophoblast layer with scattered knotted synctial trophoblast nuclei • Trophoblast rests on basement membrane • Interior of villus contains connective tissue, Hofbauer cells (macrophages) and fetal vasculature which proliferates and ramifies throughout gestation • By term, the terminal villi contain vasculosyncytial membranes in which the basement membrane of the fetal capillary apposes the basement membrane of the trophoblast • During gestation the terminal villi diminish in cross sectional area and have progressively larger cut surface composed of vascular profiles •Examples: | ||
| Clinical Correlation • Not applicable | ||
| References • Benirschke K, Kaufmann P. Pathology of the human placenta, 3rd ed. New York: Springer-Verlag, 1995, pp. 116-142. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Normal Villi
| Synopsis by: Melinda Sanders M.D. (T88220M00100)[432]
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