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| Amnion Band | ||
| Etiology • Rupture of the amnionic sac with free "bands" of amnion. • Bands can wrap around fetal extremities and/or umbilical cord to cause amputation or demise | ||
| Pathogenesis • Unknown what causes rupture • Bands entangle and mechanically constrict and amputate limbs, | ||
| Epidemiology • Spontaneous, usually not accompanying abnormal pregnancy • 1/10,000 live births with signficant (30%) mortality rate • Sporadic, non-recurrent | ||
| General Gross Description • Bands are delicate, fibrous and may be difficult to find •Examples: | ||
| General Microscopic Description • Amnionic epithelium and mesoderm • No inflammation and little degeneration •Examples: | ||
| Clinical Correlation • Outcome dependent on what the band is wrapped around • Unclear whether infants that fuse to the chorion often with massive limb or body wall defects are part of same syndrome. | ||
| References • Benirschke K, Kaufmann P. Pathology of the human placenta, 3rd ed. New York: Springer-Verlag, 1995, pp. 299-305 Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Amnion Band
| Synopsis by: Melinda Sanders M.D. (T88100M29470)[419]
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