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| Duct Hyperplasia (Non-atypical) | ||
| Etiology •Secondary to an irregular response by breast tissue to hormonal stimuli | ||
| Pathogenesis • May be due to relative or absolute excess of estrogen, decrease in progesterone, or abnormal response to either hormone by breast tissue, | ||
| Epidemiology • Reproductive age women | ||
| General Gross Description • May be associated with microcalcifications within the lumens • Gross findings may be of fibrocystic change •Examples: | ||
| General Microscopic Description • Ducts exhibit more than the usual two layer epithelium (inner cuboidal to columnar cells; outer layer of myoepithelium) • May be a solid mass of cells filling the ducts • May show papillary infoldings (with fibrovascular cores termed papillomatosis) • Maintain intact myoepithelial layer • Slit-like spaces between cells • Cells retain orientation toward lumen and/or slits • Microcalcifications within ducts •Examples: | ||
| Clinical Correlation • Found either by mammography or incidentally • In the absence of atypia increased risk of developing breast carcinoma 1.5-2x | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1093-1097. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Duct Hyperplasia (Non-atypical)
| Synopsis by: Melinda Sanders M.D. (T04000M72170)[303]
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