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| Duct Hyperplasia (Non-atypical) | ||
| Etiology Secondary to an irregular response by breast tissue to hormonal stimuli | ||
| Pathogenesis May be due to relative or absolute excess of estrogen, decrease in progesterone, or abnormal response to either hormone by breast tissue, | ||
| Epidemiology Reproductive age women | ||
| General Gross Description May be associated with microcalcifications within the lumens Gross findings may be of fibrocystic change Examples: | ||
| General Microscopic Description Ducts exhibit more than the usual two layer epithelium (inner cuboidal to columnar cells; outer layer of myoepithelium) May be a solid mass of cells filling the ducts May show papillary infoldings (with fibrovascular cores termed papillomatosis) Maintain intact myoepithelial layer Slit-like spaces between cells Cells retain orientation toward lumen and/or slits Microcalcifications within ducts Examples: | ||
| References Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1093-1097. This link will directly take you to the relevant new literature Duct Hyperplasia (Non-atypical)
| Synopsis by: Melinda Sanders M.D. (T04000M72170)[303]
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