| Papillary Carcinoma
|
Etiology
• Unknown
|
Pathogenesis
• Unknown. ?BRCA1 mutations, see discussion under infiltrating duct carcinoma.,
|
Epidemiology
• Approximately 1-2% of breast carcinoma
|
General Gross Description
• Usually 2-3 cms in size
• Approximately 1/2 located beneath the nipple (associated with bloody nipple discharge)
• Well-circumscribed
• Cystic lesions contain brown mixture of blood clot and neoplastic tissue
•Examples:
|
General Microscopic Description
• Intracystic variant may be difficult to separate from papilloma but lacks myoepithelial cell proliferation
• Stroma of the papillae is delicate compared to a papilloma
• Piled up epithelial cells with nuclear hyperchromasia and mitotic activitiy
• Periphery of cyst is fibrotic and distinguishing invasion may be difficult unless neoplasm reaches fat
•Examples:
|
References
• Rosen PP, Oberman H. Tumors of the Mammary Gland.Washington, AFIP, 1993, pp. 209-218.
For Most Current Information Search Medline at National Library of Medicine
This link will directly take you to the relevant new literature
| Papillary Carcinoma
| | Synopsis by: Melinda Sanders M.D. (T04000M82603)[310]
| |