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Papillary Carcinoma
Etiology

Unknown
Pathogenesis

Unknown. ?BRCA1 mutations, see discussion under infiltrating duct carcinoma.,
Epidemiology

Approximately 1-2% of breast carcinoma
General Gross Description

Usually 2-3 cms in size
Approximately 1/2 located beneath the nipple (associated with bloody nipple discharge)
Well-circumscribed
Cystic lesions contain brown mixture of blood clot and neoplastic tissue
•Examples:
General Microscopic Description

Intracystic variant may be difficult to separate from papilloma but lacks myoepithelial cell proliferation
Stroma of the papillae is delicate compared to a papilloma
Piled up epithelial cells with nuclear hyperchromasia and mitotic activitiy
Periphery of cyst is fibrotic and distinguishing invasion may be difficult unless neoplasm reaches fat
•Examples:
Papillary Carcinoma of Breast (Low Power)
References

Rosen PP, Oberman H. Tumors of the Mammary Gland.Washington, AFIP, 1993, pp. 209-218.

For Most Current Information Search Medline at National Library of Medicine
This link will directly take you to the relevant new literature
Papillary Carcinoma
Synopsis by: Melinda Sanders M.D. (T04000M82603)[310]
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