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| Adrenal Neuroblastoma | ||
| Etiology • May be congenital | ||
| Pathogenesis • Loss of neuroblastoma suppressor gene on distal short arm of chromosome 1 • Amplification of N-myc oncogene (seen in cases that are more aggressive), | ||
| Epidemiology • Disease of children generally < 5 yrs. of age • May be congenital | ||
| General Gross Description • Soft • Tan with areas of hemorrhage and necrosis •Examples: | ||
| General Microscopic Description • Small cells with scant cytoplasm • Hyperchromatic nuclei • May be in sheets or nests • Homer-Wright pseudo-rosettes may surround neuropil (stroma like that of white matter) • Cells are positive with neuroendocrine markers such as NSE, chromogranin, and synaptophysin •Examples: | ||
| References • Rosai J. Ackerman's Surgical Pathology. 8th ed. St. Louis, Mosby-YearBook, 1996, pp. 1026-1033. This link will directly take you to the relevant new literature Adrenal Neuroblastoma
| Synopsis by: Melinda Sanders M.D. (T93000M95003)[158]
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