Derives from adrenal medullary precursors.
Neuroblastoma may "mature" to ganglioneuroblastoma with therapy.,
Usually children under 10.
Occasionally with hypertension or watery diarrhea.
Also termed stroma rich neuroblastoma (Shimada classification).
|General Gross Description|
Depends on degree of differentiation.
Well differentiated lesions may be well circumscribed and tan.
Poorly differentiated lesions may resemble hemorrhagic, soft neuroblastomas.
|General Microscopic Description|
Small cells with darkly hyperchromatic nuclei and scant cytoplasm which may be arranged in rosettes or sheets--neuroblasts
Large cells with large nuclei and prominent nucleoli that resemble ganglion cells.
Well differentiated have only few neuroblasts, intermixed show small nests of neuroblasts, nodular has large masses of neuroblasts
Sternberg SS (ed): Diagnostic Surgical Pathology, second edition. Philadelphia, Lippincott-Raven, 1996, pp.589-590.
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||Synopsis by: Melinda Sanders M.D. (T93000M94903)