| Hashimotos thyroiditis
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Etiology
•The etiology of Hashimotos thyroiditis is unknown.
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Pathogenesis
•While the precise pathogenesis is unknown, it is believed
that Hashimotos thrioditis represents a disease of
auto-immune origin.,
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Epidemiology
•It occurs most frequently in middle aged women.
•Commonly associated with other diseases of presumed
autoimmune nature such as pernicious anemia, SLE and
diabetes mellitus.
•Strongly associated with HLA-DR3 and -DR5.
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General Gross Description
•Grossly the thyroid is initially 2 to 3 times the size
of a normal thyroid.
•The cut surface may show replacement of the normal
glistening reddish brown with areas of pale gray
somewhat fibrotic tissue reminiscent of a fibrotic
lymph node.
•Examples:
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General Microscopic Description
•Histologically, there is replacement of the thyroid
tissue with lymphoid tissue, which may show
organization into typical lymphoid follicles.
•Many acini may be surrounded by oncocytes (Hürthle
cells) which have abundant brightly eosinophilic
granular cytoplasm.
•As the disease progresses, much of the thyroid may be
replaced by scar tissue.
•Examples:
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1126
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| Hashimotos thyroiditis
| | Synopsis by: T.V.Rajan, M.D., Ph.D. (T96000M45810)[573]
| |