| Agenesis of Corpus Callosum
|
Etiology
•Both genetic and sporadic
|
Pathogenesis
•Unknown,
|
Epidemiology
•Agenesis of the corpus callsum may be part of an
extensive malformation complex or the callosum may be
partially or completely absent or hypoplastic in an
otherwise normal brain.
•The malformation is relatively
rare.
|
General Gross Description
•The brain in agenesis of the corpus callosum shows
batwing shaped ventricles as well as loss of the
corpus callosum and there is no cingulate gyrus.
•The
remainder of the abnormalities depend on what syndrome
or other malformations are associated with the defect.
In most cases there is a bundle of white matter processes
on both cerebral hemispheres in the area where
the corpus callosum should be, called the bundle of
Probst. In some patients there is a lipoma or other
tumor in the area where the corpus callosum should be.
•Examples:
|
General Microscopic Description
•None
•Examples:
|
Clinical Correlation
•Patients with agenesis of the corpus callosum may be
normal or may have neurological abnormalities dependent
on the other accompanying malformations.
|
References
• Poirer J et.al. Manual of basic neuropathology. Philadelphia: Saunders, 1990, pp.198-199.
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 1302.
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| Agenesis of Corpus Callosum
| | Synopsis by: Dr ML Grunnet (TX2700M21000)[361]
| |