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| Non-ossifying fibroma | ||
| Etiology •Unknown | ||
| Pathogenesis •Probably represent developmental defects, rather than neoplasms., | ||
| Epidemiology •Extremely common. •Found in as many as 30 to 50% of children older than two years. | ||
| General Gross Description •Usually found in the lower limb. •Found to arise eccentrically from the metaphysis of the bones around the knee joint. •Examples: | ||
| General Microscopic Description •Histologically composed of benign fibroblasts. •Frequently associated with foamy macrophages. •Examples: | ||
| Clinical Correlation •Asymptomatic. •Radiologically produce sharply demarcated lucent areas in bone. •Usually found as an incidental, asymptomatic finding on routine x-rays. •Resolve spontaneously, and are replaced by normal bone. •May result in pathological fracture, if they do not spontaneously resolve. | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1241. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Non-ossifying fibroma
| Synopsis by: T.V. Rajan M.D. Ph.D. (T1X500M74940)[91]
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