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| Cavernous Hemangioma | ||
| Etiology •Unknown. | ||
| Pathogenesis •Unknown. , | ||
| Epidemiology •Often noted in childhood. | ||
| General Gross Description •Benign vascular malformation. •Usually solitary; however, multiple cavernous hemangiomas occur in a genetic disorder, called von Hippel-Lindau disease. •Grossly, cavernous hemangiomas are blue, soft and spongy. •Examples: | ||
| General Microscopic Description •Histologically, the lesion is characterized by large, thin walled blood vessels completely filled with blood. •In contrast to other hemangiomas, vascular channels are of large diameter (hence, cavernous or like a cave). •Evidence of previous hemorrhage often seen. •Examples: | ||
| Clinical Correlation •Present as blue lesions. •Tumors are most often only of cosmetic significance. •However, when present in the brain, hemorrhage can be a lethal consequence. •In von Hippel-Lindau disease, several of these lesions are seen, in the cerebellum, brain stem and abdominal viscera. | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 507. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Cavernous Hemangioma
| Synopsis by: T.V. Rajan M.D. Ph.D. (T1X500M91210)[72]
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