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| Chondrosarcoma | ||
| Etiology •The etiology of chondrosarcoma is unknown. | ||
| Pathogenesis •Not understood., | ||
| Epidemiology •Usually a tumor of older age groups. •Approximately twice as common in men as in women. •No racial preferences have been noted. | ||
| General Gross Description •Tumors exhibit features of cartilage, including abundant ground substance and chondrocytes. •Areas of calcification, necrosis and hemorrhage are seen in rapidly growing tumors. •Myxoid variants exhibit a viscous and gelatinous consistency. •Cellular atypia increases with poorly differentiated tumors. •Examples: | ||
| General Microscopic Description •Histologically, chondrosarcomas can be divided into three grades - grade 1 (most differentiated) to grade 3 (most anaplastic) •Grade 1 tumors resemble normal cartilage closely, with little deviation from normal histology. •Grade 3 tumors can show considerable cellular atypia. •Most common grade of chondrosarcoma is grade 1. •More aggressive grades show areas of necrosis and hemorrhage. •The myxoid variant exhibits areas of myxomatous matrix. •Examples: | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1240. This link will directly take you to the relevant new literature Chondrosarcoma
| Synopsis by: T.V. Rajan M.D. Ph.D. (T1X500M92203)[56]
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