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| Liposarcoma | ||
| Etiology •Unknown | ||
| Pathogenesis •Unknown, | ||
| Epidemiology •Tumor of adult life, with a peak incidence between 40 and 60 years of age. •Approximately 55 to 60% of tumors occur in men. •Retroperitoneal tumors occur somewhat more frequently in women. •There is no evidence that any race or geographical area is more prone to develop liposarcomas. | ||
| General Gross Description •The three most common locations are the thigh, the retroperitoneum, and the inguinal region. •Grossly, the sarcomas are large (5 to 10 centimeters) lesions that are well-circumscribed. •Liposarcomas typically manifest a lobulated appearance. •Cut section may reveal a mucinous appearance, especially if the myxoid component is prominent. •Typically, at least some evidence of yellow color, due to the lipid material, is present. •Examples: | ||
| General Microscopic Description •Histologically, the most common type is the myxoid type. •The tumor has three components: proliferating lipoblasts, a delicate capillary network, and a myxoid matrix containing abundant ground substance. •The typical feature of a liposarcoma is the presence of lipoblasts, usually appearing as cells with a foamy or signet ring appearance. •Some of these cells may,with an increase in lipid accumulation, resemble adult fat cells. •A branching capillary network, resembling a chickenwire fence, is one of the typical features of the myxoid liposarcoma. •The myxoid component also contains stellate myxomatous cells. •Some liposarcomas are poorly differentiated with small round cells resembling a malignant lymphoma. •However, typical lipoblasts and myxoid cells are often seen. •Examples: | ||
| References • • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1262. This link will directly take you to the relevant new literature Liposarcoma
| Synopsis by: T.V. Rajan M.D. Ph.D. (T1X000M88503)[90]
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