Tumor of adult life, with a peak incidence between 40 and 60 years of age.
Approximately 55 to 60% of tumors occur in men.
Retroperitoneal tumors occur somewhat more frequently in women.
There is no evidence that any race or geographical area is more prone to develop liposarcomas.
|General Gross Description|
The three most common locations are the thigh, the retroperitoneum, and the inguinal region.
Grossly, the sarcomas are large (5 to 10 centimeters) lesions that are well-circumscribed.
Liposarcomas typically manifest a lobulated appearance.
Cut section may reveal a mucinous appearance, especially if the myxoid component is prominent.
Typically, at least some evidence of yellow color, due to the lipid material, is present.
|General Microscopic Description|
Histologically, the most common type is the myxoid type.
The tumor has three components: proliferating lipoblasts, a delicate capillary network, and a myxoid matrix containing abundant ground substance.
The typical feature of a liposarcoma is the presence of lipoblasts, usually appearing as cells with a foamy or signet ring appearance.
Some of these cells may,with an increase in lipid accumulation, resemble adult fat cells.
A branching capillary network, resembling a chickenwire fence, is one of the typical features of the myxoid liposarcoma.
The myxoid component also contains stellate myxomatous cells.
Some liposarcomas are poorly differentiated with small round cells resembling a malignant lymphoma.
However, typical lipoblasts and myxoid cells are often seen.
Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1262.
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||Synopsis by: T.V. Rajan M.D. Ph.D. (T1X000M88503)