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Erythema nodosum
Etiology

Unknown
Pathogenesis

Believed to be a hypersensitvity reaction to varied insults.
The precise cause of erythema nodosum is unknown, but it can often occur as a sequel to bacterial infections, in response to some drugs and accompanying some fungal infections.,
Epidemiology

Common disorder
General Gross Description

Erythema nodosum is one form of acute inflammation of the soft tissue of the skin (panniculitis).
The lesion is often not clearly visible, but can palpated as an area of induration in the subcutaneous tissues.
•Examples:
General Microscopic Description

Histologically, there are two patterns.
If the inflammation primarily involves the septa separating the subcutaneous adipose tissue into lobules, there is some thickening of these septa with the presence of inflammatory cells.
If the inflammation attacks primarily the nodules of fat, areas of fat necrosis with accumulation of inflammatory cells and macrophages is seen.
•Examples:
Erythema Nodosum Erythema Nodosum
References

Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1196.
Harrison's Principles of Internal Medicine, 13th Edition: Isselbach et. al. (eds). New York, McGraw-Hill, 1994, pp. 383.

For Most Current Information Search Medline at National Library of Medicine
This link will directly take you to the relevant new literature
Erythema nodosum
Synopsis by: T.V.Rajan, M.D., Ph.D. (T01000M45620)[520]
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