|
|
|
|
|
|
|
| Erythema nodosum | ||
| Etiology •Unknown | ||
| Pathogenesis •Believed to be a hypersensitvity reaction to varied insults. •The precise cause of erythema nodosum is unknown, but it can often occur as a sequel to bacterial infections, in response to some drugs and accompanying some fungal infections., | ||
| Epidemiology •Common disorder | ||
| General Gross Description •Erythema nodosum is one form of acute inflammation of the soft tissue of the skin (panniculitis). •The lesion is often not clearly visible, but can palpated as an area of induration in the subcutaneous tissues. •Examples: | ||
| General Microscopic Description •Histologically, there are two patterns. •If the inflammation primarily involves the septa separating the subcutaneous adipose tissue into lobules, there is some thickening of these septa with the presence of inflammatory cells. •If the inflammation attacks primarily the nodules of fat, areas of fat necrosis with accumulation of inflammatory cells and macrophages is seen. •Examples: | ||
| Clinical Correlation •It characterisically presents as an exquisitely tender, erythematous lesion. •Erythema nodosum is usually self-limiting and no specific treatment is available. | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 1196. • Harrison's Principles of Internal Medicine, 13th Edition: Isselbach et. al. (eds). New York, McGraw-Hill, 1994, pp. 383. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Erythema nodosum
| Synopsis by: T.V.Rajan, M.D., Ph.D. (T01000M45620)[520]
| |
|
|
|
|
|
|