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| Metastatic malignancy in a lymph node | ||
| Etiology •Secondary to malignancies elsewhere, almost always carcinoma, or systemic involvement by lymphoma. •Rare event for sarcoma. | ||
| Pathogenesis •Tumors invade lymphatics and spread to the local draining lymph node. •Here, colonization occurs first underneath the capsule in the marginal sinus. •Subsequently, the entire lymph node may be involved., | ||
| Epidemiology •Common. | ||
| General Gross Description •Grossly, the lymph node may be of normal size or significantly enlarged. •Depending upon the rate of growth of the tumor, there may be necrosis, cystic change or hemorrhage. •In extreme cases, cross section may reveal a completely or partially necrotic node, with the center appearing as a white pus-like material. •Examples: | ||
| General Microscopic Description •Microscopically, the tumor may be seen initially as small deposits of tumor resembling the primary tumor in the marginal sinus. •Subsequently, deposits may be seen in the medullary region of the lymph node. •In extreme cases, the entire lymph node may be replaced by tumor, leaving behind very little normal lymphoid tissue. •Significant areas of necrosis, hemorrhage and liquefaction degeneration may be seen. •Examples: | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th ed. Philadelphia, W.B. Saunders, 1994, pp. 297. This link will directly take you to the relevant new literature Metastatic malignancy in a lymph node
| Synopsis by: T.V.Rajan, M.D., Ph.D. (T08000M81406)[607]
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