| Leukemic or Lymphomatous Involvement of Spleen
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Etiology
• Etiology that of specific leukemia or lymphoma
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Pathogenesis
• Pathogenesis that of specific leukemia or lymphoma,
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Epidemiology
• Epidemiology that of specific leukemia or lymphoma
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General Gross Description
• May be tiny nodules in B cell areas (low grade follicular lymphoma)
• Large, irregular gray tan fleshy nodules (high grade lymphoma)
• Multiple gray tan nodules in Hodgkin's disease (uncommon)
• Diffuse often massive enlargment with chronic leukemias, esp. myelogenous leukemia
•Examples:
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General Microscopic Description
• Infiltrates of the neoplastic cell
• Leukemias may start as white pulp involvement (lymphocytic) and become diffuse
• Lymphomas may show aggregates of neoplastic cells typical of the specific subtype
•Examples:
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References
• Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 634-667.
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| Leukemic or Lymphomatous Involvement of Spleen
| | Synopsis by: Melinda Sanders M.D. (T07000M95903)[415]
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