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| Granuloma N.O.S. | ||
| Etiology • Various of organisms including Mycobacteria, Histoplasma, and Coccidioides • Hypersensitivity to allergens • Sarcoidosis • Wegener's granulomatosis orChurg-Strauss granulomatosis • Foreign material • Rheumatoid arthritis • Lymphomatoid granulomatosis • Unknown | ||
| Pathogenesis • If acute inflammatory response fails to deal with antigen then granuloma may form secondary to cell-mediated response • Generally follows if antigen cannot be readily destroyed, | ||
| Epidemiology • That of the underlying disease process | ||
| General Gross Description • Round firm nodules which may have soft center if necrotizing •Examples: | ||
| General Microscopic Description • Aggregate of macrophages accompanied by multinucleated macrophages with identical nuclei • Center may be necrotic • Macrophages may contain recognizable foreign material or organisms • Lymphocytes ring the aggregate •Examples: | ||
| Clinical Correlation • Granulomas may eventually be completely replaced by dense collagenous connective tissue | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 324-327 and 712-714. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Granuloma N.O.S.
| Synopsis by: Melinda Sanders M.D. (T28000M44000)[435]
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