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| Infarct | ||
| Etiology • Occlusion of pulmonary artery or arteriole. | ||
| Pathogenesis • Vascular obstruction results in necrosis of tissue within that vessel's distribution • With some bronchial flow the lesions are hemorrhagic • End artery obstruction results in pleural based lesions • Healing is by scarrring, | ||
| Epidemiology • Approximately 10% of emboli lead to infarct • Generally patients who infarct have compromised bronchial vascular circulation | ||
| General Gross Description • Triangular firm lesions which are raised, firm and reddish-purple initially with base of triangle at pleura • Gray tan, retracted after healing •Examples: | ||
| General Microscopic Description • Hemorrhagic with necrosis of the septae • Heals by fibrosis •Examples: | ||
| Clinical Correlation • Outcome dependent on underlying pulmonary and cardiac disease. • Recurrent emboli can result in pulmonary hypertension | ||
| References • Cotran RS, Kumar V, Robbins SL: Robbins Pathologic Basis of Disease. 5th edition. Philadelphia, W.B. Saunders, 1994, pp. 679-680. Please be patient during transfer. Medline will open in a new window. To return, close the Medline Window Infarct
| Synopsis by: Melinda Sanders M.D. (T28000M54700)[354]
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